Advantages of peritoneal insulin infusion

Physiological effect of insulin

• In non-diabetics, the insulin is produced prehepatically by the pancreas, i.e., directly before the liver.

• In conventional therapy, insulin is injected or infused subcutaneously and travels through the veins to the heart and from there to the liver.

• In peritoneal infusion—that is, when insulin is applied directly into the abdominal cavity—the majority of insulin travels directly to the liver through the blood vessel lining, which corresponds to the physiological route.

Benefits of the fast insulin effect

• In the subcutaneous insulin injection, the insulin comes in roundabout way and in less concentration to the liver. Because of the slow resorption from the subcutaneous tissue, a fast postprandiale insulinism of the liver is impeded. A rapid response is possible to hypoglycaemia or hyperglycaemia is also hardly possible!

• With intraperitoneal insulin infusion, the insulin takes effect within a few minutes. The patient can also be certain that the quantity of insulin required will have the anticipated effect. A rapid response to hyperglycaemia is therefore possible.